Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review

Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review

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BackgroundNeuropsychiatric disturbances and chorea are less recognized consequences of polycythemia vera (PV), and their role in post-PV myelofibrosis (MF) has not been reported.Clinical features that predict post-PV MF lack specificity.Case presentationWe describe an elderly patient with PV who developed acute-onset reversible neuropsychiatric disturbances accompanied King Sleigh Headboard by generalized chorea and was finally diagnosed with post-PV MF after a bone marrow examination.We also reviewed four cases of late PV associated with neuropsychiatric symptoms since 1966 and analyzed their clinical characteristics and therapeutic effects.

ConclusionOur case indicates that Janus kinase 2 (JAK2)-related PV is a treatable cause of late-onset chorea and that chorea may herald the deterioration of hematological parameters.Our case provides a clinically specific representation of post-PV MF.Patients with a long course of PV are recommended to undergo bone marrow re-examinations when they present with neuropsychiatric symptoms to achieve an early Shorts diagnosis of post-PV MF.